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KMID : 0370219870310050322
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Yakhak Hoeji
1987 Volume.31 No. 5 p.322 ~ p.329
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Spectrophotometric Determination of Phenothiazine Derivatives by using Picric acid as Electron Acceptor
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옥치완/Ock CW
신태용/Shin TY
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Abstract
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A rapid and sensitive spectrophotometric method has been developed for quantitation of some phenothiazine derivatives (PTZDS). The method depends on the formation of insoluble yellow complexes between PTZDS and picric acid (PCA) in aqueous layer. These complexes are quantitatively extracted from aqueous phase into chloroform. The binding ratio of PTZDS-PCA complexes were presumed as PTZDS-1 to PCA-1 by means of mole ratio and continuous variation methods. The complexes are stable for more than 24 hours in chloroform layer at room temperature. Most of compounds associated with pharmaceutical preparation of PTZDS do not interfere with this method. However, chlorpheniramine and diphenhydramine interfere with the method. The binding state of PTZDS-PCA complexes were presumed by IR and 1H-NMR spectra as intermolecular hydrogen bonding.
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